A year in the life of Alice Klieg, a woman with Borderline personality disorder who wins the Mega Millions lottery, quits her meds and buys her own talk show.
| Actor | Role |
|---|---|
 Kristen WiigAlice Klieg | Alice Klieg |
 James MarsdenRich Ruskin | Rich Ruskin |
 Linda CardelliniGina Selway | Gina Selway |
 Wes BentleyGabe Ruskin | Gabe Ruskin |
 Jennifer Jason LeighDeb Moseley | Deb Moseley |
 Alan TudykTed Thurber | Ted Thurber |
 Tim RobbinsDr. Daryl Moffet | Dr. Daryl Moffet |
 Joan CusackDawn Hurley | Dawn Hurley |
 Thomas MannRainer Ybarra | Rainer Ybarra |
 Rose AbdooConnie | Connie |
 Shanna StrongTeenage Alice | Teenage Alice |
 Kulap VilaysackGrace Dao | Grace Dao |
 Loretta DevineBarb Vaughn | Barb Vaughn |
| JJoyce Hiller PivenMiriam Klieg | Miriam Klieg |
 Jack WallaceBud Klieg | Bud Klieg |
 Mitch SilpaDerek | Derek |
 George BasilTechnical Director #2 | Technical Director #2 |