Centers on Ellie, the psychiatrist in charge of the weekend shift of Bellevue Hospital psychiatric unit.
| Actor | Role |
|---|---|
 Eric WinterJared Knox | Jared Knox |
 Yaya DaCostaVanessa | Vanessa |
 Janet McTeerDiane Wallace | Diane Wallace |
 Lauren AmbroseEllie Harlowe | Ellie Harlowe |
 Felix SolisJudge Bernard Chavez | Judge Bernard Chavez |
 Amber Stevens WestClaire Cohen | Claire Cohen |
 Patricia KalemberLucinda | Lucinda |
 XzibitChuck | Chuck |
 Daniel LondonSteven | Steven |
 Joseph D'OnofrioNico | Nico |
 Jennifer MudgeMira Kennerly | Mira Kennerly |
 Margaret Anne FlorenceMaggie Woodrow | Maggie Woodrow |
 Mike HoustonSoutherland | Southerland |
 Yin ChangDaisy Wong | Daisy Wong |
 Andy PowersTom Harlow | Tom Harlow |
 John SperedakosVictor | Victor |
| BBrian MorvantLeo | Leo |