A matriarch of a dysfunctional family is pushed to her tipping point by the disappearance of her son.
| Actor | Role |
|---|---|
 Catherine KeenerNancy Green | Nancy Green |
 Anton YelchinMaxwell Green | Maxwell Green |
 Kaitlyn DeverLily Green | Lily Green |
 Riley KeoughElisa Green | Elisa Green |
 Annie StarkeMadeline Green | Madeline Green |
 Molly ShannonDeborah | Deborah |
 Justin ChatwinTomas | Tomas |
 Austin AbramsDavey | Davey |
 Debra MooneyGrandma | Grandma |
 Maya RudolphJoanne | Joanne |
 Cary ElwesFrank Harper | Frank Harper |
 Michelle HurdTania | Tania |
 Sarah RamosJill | Jill |
| MMary E. QuickPsychic | Psychic |
 Mark FamigliettiMan at Track | Man at Track |
 Adrian EnscoeDan | Dan |
 Ed PeedCaretaker | Caretaker |
 Sheila StasackCarole | Carole |
 Lucinda JenneyDora | Dora |
| SScottie McLaughlinDrag Queen | Drag Queen |
| GGiani BoernerYoung Elisa | Young Elisa |
| KKelby Turner AkinOfficer | Officer |
 Tamara HickeyMrs. B | Mrs. B |
| EEmily WachtelMrs. C | Mrs. C |
| KKaren ScaliaMrs. D | Mrs. D |
| CCollin KnightOderly | Oderly |
| RRobert SabinoTown Car Driver | Town Car Driver |
| JJoseph GomesYoung Maxwell | Young Maxwell |
| DDalila MeyersYoung Madeline | Young Madeline |
| BBob KeddieBoy Wonder | Boy Wonder |