A look at the mystique of road movies, combining interviews, film clips, music, photography, literature and a narrative storyline featuring Paul Rudd and Tom McCarthy.
| Actor | Role |
|---|---|
 Allison AndersHerself | Herself |
 Jeanine BasingerHerself | Herself |
 Robert BentonHimself | Himself |
 Karen BlackHerself | Herself |
 Peter BogdanovichHimself | Himself |
| JJeff BrouwsHimself | Himself |
 William S. BurroughsTom the Priest | Tom the Priest |
 Alfonso CuarónHimself | Himself |
 Kat DenningsLila | Lila |
 Chris EyreSelf | Self |
 Monte HellmanHimself | Himself |
 Dennis HopperHimself | Himself |
 Callie KhouriHerself | Herself |