Victoria "V.I" Warshawski is a Chicago based private detective who agrees to babysit for her new boyfriend; then he is murdered. Being the detective type, she makes the murder her next case. In doing so she befriends the victim's daughter, Kat, and together they set out to crack the case.
| Actor | Role |
|---|---|
 Kathleen TurnerVictoria 'V.I.' Warshawski | Victoria 'V.I.' Warshawski |
 Jay O. SandersMurray Ryerson | Murray Ryerson |
 Charles DurningDet. Lt. Bobby Mallory | Det. Lt. Bobby Mallory |
 Angela GoethalsKat Grafalk, Bernard's Daughter | Kat Grafalk, Bernard's Daughter |
 Nancy PaulPaige Wilson Grafalk | Paige Wilson Grafalk |
 Frederick CoffinHorton | Horton |
 Charles McCaughanTrumble | Trumble |
 Stephen MeadowsBoom-Boom | Boom-Boom |
 Wayne KnightSmeissen | Smeissen |
| LLynnie GodfreySal | Sal |
 Anne PitoniakLotty | Lotty |
 Stephen RootMickey | Mickey |
 Robert ClotworthyPhilip Pugh | Philip Pugh |
| TTom AllardBig Eddie | Big Eddie |
 Mike HagertyBabe | Babe |
 Lee ArenbergFlesh | Flesh |
 Mike BacarellaCabbie | Cabbie |
 John BeasleyErnie | Ernie |
| EEverett SmithMcGraw | McGraw |
| HHerb MullerContreras | Contreras |
 Theresa BellStacy | Stacy |
| GGeof PrysirrRon Whortley | Ron Whortley |
| SSandra FosterBank Teller | Bank Teller |
| GGregg AlmquistBank Manager | Bank Manager |
 Gene HartlineThug #1 | Thug #1 |
 Gary EpperThug #2 | Thug #2 |