 Lupita Nyong'oAdelaide Wilson / Red | Adelaide Wilson / Red |
 Winston DukeGabe Wilson / Abraham | Gabe Wilson / Abraham |
 Elisabeth MossKitty Tyler / Dahlia | Kitty Tyler / Dahlia |
 Tim HeideckerJosh Tyler / Tex | Josh Tyler / Tex |
 Shahadi Wright JosephZora Wilson / Umbrae | Zora Wilson / Umbrae |
 Evan AlexJason Wilson / Pluto | Jason Wilson / Pluto |
 Yahya Abdul-Mateen IIRussell Thomas / Weyland | Russell Thomas / Weyland |
 Anna DiopRayne Thomas / Eartha | Rayne Thomas / Eartha |
| CCali SheldonBecca Tyler / Io | Becca Tyler / Io |
| NNoelle SheldonLindsey Tyler / Nix | Lindsey Tyler / Nix |
 Madison CurryYoung Adelaide Wilson / Young Red | Young Adelaide Wilson / Young Red |
| AAshley McKoyTeenage Adelaide Wilson / Teenage Red | Teenage Adelaide Wilson / Teenage Red |
 Napiera GrovesDr. Foster | Dr. Foster |
| LLon GowanDon | Don |
| AAlan FrazierFerdie / Jeremiah | Ferdie / Jeremiah |
 Duke NicholsonDanny / Tony | Danny / Tony |
 Dustin YbarraTroy / Brand | Troy / Brand |
| NNathan HarringtonGlen / Jack | Glen / Jack |
 Kara HaywardNancy / Syd | Nancy / Syd |
 Jordan PeeleDying Rabbit / Fun House Narrator (voice) (uncredited) | Dying Rabbit / Fun House Narrator (voice) (uncredited) |
 Darrel CherneyNews Anchor (uncredited) | News Anchor (uncredited) |
| JJames CobbDon (uncredited) | Don (uncredited) |
 Alessandro GarciaEMT (uncredited) | EMT (uncredited) |
| DDavid M Sandoval Jr.Father of Family on Beach (uncredited) | Father of Family on Beach (uncredited) |
