 Ed AsnerCarl Fredricksen (voice) | Carl Fredricksen (voice) |
 Christopher PlummerCharles Muntz (voice) | Charles Muntz (voice) |
 Jordan NagaiRussell (voice) | Russell (voice) |
 Bob PetersonDug / Alpha (voice) | Dug / Alpha (voice) |
 Delroy LindoBeta (voice) | Beta (voice) |
| JJerome RanftGamma (voice) | Gamma (voice) |
 John RatzenbergerConstruction Foreman Tom (voice) | Construction Foreman Tom (voice) |
 David KayeNewsreel Announcer (voice) | Newsreel Announcer (voice) |
| EElie DocterYoung Ellie (voice) | Young Ellie (voice) |
 Jeremy LearyYoung Carl (voice) | Young Carl (voice) |
 Mickie McGowanPolice Officer Edith (voice) | Police Officer Edith (voice) |
 Danny MannConstruction Worker Steve (voice) | Construction Worker Steve (voice) |
 Donald FulliloveNurse George (voice) | Nurse George (voice) |
 Jess HarnellNurse AJ (voice) | Nurse AJ (voice) |
 Josh CooleyOmega (voice) | Omega (voice) |
 Pete DocterCampmaster Strauch (voice) | Campmaster Strauch (voice) |
 Mark AndrewsAdditional Voices (voice) | Additional Voices (voice) |
 Bob BergenAdditional Voices (voice) | Additional Voices (voice) |
 Brenda ChapmanAdditional Voices (voice) | Additional Voices (voice) |
| EEmma CoatsAdditional Voices (voice) | Additional Voices (voice) |
 John CyganAdditional Voices (voice) | Additional Voices (voice) |
 Paul EidingAdditional Voices (voice) | Additional Voices (voice) |
 Tony FucileAdditional Voices (voice) | Additional Voices (voice) |
 Teresa GanzelAdditional Voices (voice) | Additional Voices (voice) |
 Sherry LynnAdditional Voices (voice) | Additional Voices (voice) |
 Laraine NewmanAdditional Voices (voice) | Additional Voices (voice) |
 Teddy NewtonAdditional Voices (voice) | Additional Voices (voice) |
 Jeff PidgeonAdditional Voices (voice) | Additional Voices (voice) |
 Valerie LaPointeAdditional Voices (voice) | Additional Voices (voice) |
 Jan RabsonAdditional Voices (voice) | Additional Voices (voice) |
