Mariel and Deena were strangers until they became the best of friends because of the similarities in the pain that they had experienced. Their friendship is put to the test when one of them decides to get married.
| Actor | Role |
|---|---|
 Bea AlonzoMariel Salvador | Mariel Salvador |
 Angelica PanganibanDeena Yambao | Deena Yambao |
 Richard GutierrezJustin Saavedra | Justin Saavedra |
 Ian VeneracionBene | Bene |
 Rosanna RocesJanice | Janice |
 Gloria DiazHelen | Helen |
 Via AntonioSarah | Sarah |
| PPhilip Joshua EndrinalPochoy | Pochoy |
 Issa LittonCara | Cara |
 João ConstanciaAlfred | Alfred |
 Allan PauleDodi | Dodi |
 Anthony JenningsMark | Mark |
 Keagan De JesusTJ | TJ |
 Kit ThompsonKiko | Kiko |
 Victor SilayanLuke | Luke |
 Xia VigorMareena | Mareena |
| LLuke AlfordYoung Mark | Young Mark |
 Robbie WachtelYoung TJ | Young TJ |
 Regine TolentinoMariel's Boss | Mariel's Boss |
 Allan VillafuerteDrew | Drew |
 Marnie LapusDr. Evalle | Dr. Evalle |
 Raul MontesaDoctor | Doctor |
| MMitchie Ann VinluanMichelle (Helen's PA) | Michelle (Helen's PA) |
| KKiks FerrerEvents Host | Events Host |
 Ali ForbesFlirting Girl | Flirting Girl |
| EElizabeth MusngiDoctor | Doctor |
 Eda NolanConcert Girl | Concert Girl |
 Alora SasamConcert Girl | Concert Girl |