UFC on ESPN 40: Santos vs. Hill was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 6, 2022, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A light heavyweight bout between former UFC Light Heavyweight title challenger Thiago Santos and Jamahal Hill headlined the event. The heavyweight and women's flyweight finals of The Ultimate Fighter: Team Peña vs. Team Nunes took place at the event.
| Actor | Role |
|---|---|
 Jamahal HillSelf | Self |
 Thiago SantosSelf | Self |
 Geoff NealSelf | Self |
 Vicente LuqueSelf | Self |
 Mohammed UsmanSelf | Self |
 Zac PaugaSelf | Self |
 Juliana MillerSelf | Self |
 Brogan Walker-SanchezSelf | Self |
 Sergey SpivakSelf | Self |
 Augusto SakaiSelf | Self |
 Terrance McKinneySelf | Self |
 Erick GonzalezSelf | Self |
 Michał OleksiejczukSelf | Self |
 Sam AlveySelf | Self |
 Bryan BattleSelf | Self |
 Takashi SatoSelf | Self |
 Cory McKennaSelf | Self |
 Miranda GrangerSelf | Self |
 Mayra Bueno SilvaSelf | Self |
 Stephanie EggerSelf | Self |