UFC 22: Only One Can be Champion was a mixed martial arts event held by the Ultimate Fighting Championship on September 24, 1999 at the Lake Charles Civic Center in Lake Charles, Louisiana.
| Actor | Role |
|---|---|
 Frank ShamrockSelf | Self |
 Tito OrtizSelf | Self |
 Jens PulverSelf | Self |
| AAlfonso AlcarezSelf | Self |
 Brad KohlerSelf | Self |
| SSteve JudsonSelf | Self |
 Tim LajcikSelf | Self |
| RRon WatermanSelf | Self |
 John LewisSelf | Self |
| LLowell AndersonSelf | Self |
 Matt HughesSelf | Self |
| VValeri IgnatovSelf | Self |
 Jeremy HornSelf | Self |
| JJason GodseySelf | Self |
 Chuck LiddellSelf | Self |
| PPaul JonesSelf | Self |