 James StewartMarshal Guthrie McCabe | Marshal Guthrie McCabe |
 Richard WidmarkFirst Lt. Jim Gary | First Lt. Jim Gary |
 Shirley JonesMarty Purcell | Marty Purcell |
 Linda CristalElena de la Madriaga | Elena de la Madriaga |
 Andy DevineSgt. Darius P. Posey | Sgt. Darius P. Posey |
 John McIntireMajor Frazer | Major Frazer |
 Paul BirchJudge Edward Purcell | Judge Edward Purcell |
 Willis BoucheyMr. Harry J. Wringle | Mr. Harry J. Wringle |
 Henry BrandonChief Quanah Parker | Chief Quanah Parker |
 Harry Carey Jr.Ortho Clegg | Ortho Clegg |
 Olive CareyMrs. Abby Frazer | Mrs. Abby Frazer |
 Ken CurtisGreeley Clegg | Greeley Clegg |
| CChet DouglasDeputy Ward Corby | Deputy Ward Corby |
| AAnnelle HayesBelle Aragon | Belle Aragon |
| DDavid KentRunning Wolf | Running Wolf |
 Anna LeeMrs. Malaprop | Mrs. Malaprop |
 Jeanette NolanMrs. Mary McCandless | Mrs. Mary McCandless |
 John QualenOle Knudsen | Ole Knudsen |
 Ford RaineyRev. Henry Clegg | Rev. Henry Clegg |
 Woody StrodeStone Calf | Stone Calf |
 O.Z. WhiteheadLt. Whitehead | Lt. Whitehead |
 Chuck RobersonComanche | Comanche |
 Gertrude AstorMrs. Wringle (uncredited) | Mrs. Wringle (uncredited) |
| BBobette BentleyMinor Role (uncredited) | Minor Role (uncredited) |
 Bill BorzageSettler (uncredited) | Settler (uncredited) |
| DDanny BorzageTrooper (uncredited) | Trooper (uncredited) |
| JJim BrewerJack (uncredited) | Jack (uncredited) |
 Regina CarrolWakanana (uncredited) | Wakanana (uncredited) |
 Ruth CliffordWoman (uncredited) | Woman (uncredited) |
| JJane CrowleySettler (uncredited) | Settler (uncredited) |
