| SScott PetersonSelf (archive footage) | Self (archive footage) |
| LLaci PetersonSelf (archive footage) | Self (archive footage) |
 David MuirSelf - Co-Host | Self - Co-Host |
 Elizabeth VargasSelf - Co-Host | Self - Co-Host |
 Dan AbramsSelf | Self |
 Gloria AllredSelf | Self |
 Nancy GraceSelf | Self |
| SStacy BoyersSelf - Laci's Friend | Self - Laci's Friend |
| BBirgit FladagerSelf - Chief Deputy District Attorney | Self - Chief Deputy District Attorney |
| MMark GeragosSelf - Scott Peterson's Defense Attorney | Self - Scott Peterson's Defense Attorney |
| JJon BuehlerSelf - Detective, Modesto PD (CA) | Self - Detective, Modesto PD (CA) |
| AAllen BrocchiniSelf - Detective, Modesto PD (CA) | Self - Detective, Modesto PD (CA) |
| MMike BelmessieriSelf - Juror | Self - Juror |
| GGregory BeratlisSelf - Juror | Self - Juror |
| JJustin FalconerSelf - Juror | Self - Juror |
| AAlfred DelucciSelf - Judge (archive footage) | Self - Judge (archive footage) |
| AAmber FreySelf - Scott's Mistress (archive footage) | Self - Scott's Mistress (archive footage) |
| RRon GrantskiSelf - Laci's Stepfather (archive footage) | Self - Laci's Stepfather (archive footage) |