When an alien plague turns Transformers into relentless destroyers, the universe's only hope lies in reviving Optimus Prime, who must unite with old enemies to reclaim the Matrix of Leadership and save Cybertron.
| Actor | Role |
|---|---|
 Peter CullenOptimus Prime | Optimus Prime |
 Dan GilvezanBumblebee / Goldbug | Bumblebee / Goldbug |
 Aron KincaidSky Lynx | Sky Lynx |
 Frank WelkerGalvatron / Mixmaster / Rumble / Skywarp / Soundwave / Superion / Wheelie | Galvatron / Mixmaster / Rumble / Skywarp / Soundwave / Superion / Wheelie |
 Scatman CrothersJazz | Jazz |
 John Moschitta Jr.Blurr | Blurr |