In the aftermath of the Titans' conflict that concluded into Optimus Prime's death, the rest of the Transformers must stand together in order to stop Megatronus from wiping out their species forever. During their search for the Requiem Blaster, more mysteries about Cybertron’s past will be uncovered, and a new Prime will be chosen.
| Actor | Role |
|---|---|
 Jaime KingSolus Prime (voice) | Solus Prime (voice) |
 Nuufolau Joel SeanoaPredaking (voice) | Predaking (voice) |
 Peter CullenOptimus Prime (voice) | Optimus Prime (voice) |
 Judd NelsonHot Rod / Rodimus Cron / Rodimus Unicronus / Unicron (voice) | Hot Rod / Rodimus Cron / Rodimus Unicronus / Unicron (voice) |
 Kari WahlgrenVictorion (voice) | Victorion (voice) |
 Wil WheatonPerceptor (voice) | Perceptor (voice) |
 Ron PerlmanOptimus Primal / Optimal Optimus (voice) | Optimus Primal / Optimal Optimus (voice) |
 Frank TodaroSludge and Starscream (voice) | Sludge and Starscream (voice) |
 Charlie GuzmanMenasor (voice) | Menasor (voice) |
 Mark HamillMegatronus / The Fallen (voice) | Megatronus / The Fallen (voice) |
| JJamie IracleanosSlug (voice) | Slug (voice) |
 Jason MarnochaMegatron (voice) | Megatron (voice) |
 Matthew PatrickComputron and Swoop (voice) | Computron and Swoop (voice) |
 Patrick SeitzOverlord (voice) | Overlord (voice) |
| MMikey WaySnarl (voice) | Snarl (voice) |
 Gregg BergerGrimlock (voice) | Grimlock (voice) |
 Abby TrottWindblade (voice) | Windblade (voice) |