 Chris HemsworthOrion Pax / Optimus Prime (voice) | Orion Pax / Optimus Prime (voice) |
 Brian Tyree HenryD-16 / Megatron (voice) | D-16 / Megatron (voice) |
 Scarlett JohanssonElita-1 (voice) | Elita-1 (voice) |
 Keegan-Michael KeyB-127 (voice) | B-127 (voice) |
 Jon HammSentinel Prime (voice) | Sentinel Prime (voice) |
 Steve BuscemiStarscream (voice) | Starscream (voice) |
 Laurence FishburneAlpha Trion (voice) | Alpha Trion (voice) |
 Vanessa LiguoriAirachnid (voice) | Airachnid (voice) |
 Jon BaileySoundwave (voice) | Soundwave (voice) |
 Jason Konopisos-AlvarezShockwave / Guard 2 (voice) | Shockwave / Guard 2 (voice) |
 Evan Michael LeeJazz (voice) | Jazz (voice) |
 James RemarZeta Prime (voice) | Zeta Prime (voice) |
 Isaac C. Singleton, Jr.Darkwing (voice) | Darkwing (voice) |
 Steve BlumAnnouncer Bot / Guard 1 (voice) | Announcer Bot / Guard 1 (voice) |
 Jinny ChungChromia / Arcee (voice) | Chromia / Arcee (voice) |
 Josh CooleyControl Room Guys / PA System / Skywarp (voice) | Control Room Guys / PA System / Skywarp (voice) |
| DDillon BryanInjured Racer (voice) | Injured Racer (voice) |
