A submarine commander is on a relentless pursuit of a Japanese aircraft carrier in the South Seas during World War II.
| Actor | Role |
|---|---|
 Glenn FordLt. Cmdr. Barney Doyle | Lt. Cmdr. Barney Doyle |
 Ernest BorgnineLt. Archer 'Archie' Sloan | Lt. Archer 'Archie' Sloan |
 Diane BrewsterJane Doyle | Jane Doyle |
 Dean JonesLt. Jake 'Fuzz' Foley | Lt. Jake 'Fuzz' Foley |
 L.Q. Jones'Hash' Benson | 'Hash' Benson |
 Philip OberAdm. Samuel Setton | Adm. Samuel Setton |
 Richard CarlyleCmdr. Don Adams | Cmdr. Don Adams |
 Fredd WayneOrville 'Goldy' Goldstein | Orville 'Goldy' Goldstein |
 Don KeeferEns. Ron Milligan | Ens. Ron Milligan |
 Robert HardyLt. Redley | Lt. Redley |
 Paul PicerniLt. Burt Fisher | Lt. Burt Fisher |
 Kimberly BeckDede Doyle | Dede Doyle |
| OOliver CrossNightclub Patron | Nightclub Patron |
| HHoward DaytonWalker | Walker |
 Sam EdwardsSub Radio Operator | Sub Radio Operator |
 Biff ElliotLt. Paul Buckeye | Lt. Paul Buckeye |
 Al Freeman Jr.Sam Baker | Sam Baker |
 Frank GorshinSub Crewman | Sub Crewman |
 Norman GrabowskiSub Crewman | Sub Crewman |
 Louis QuinnCrewman Metcalf | Crewman Metcalf |
 William SchallertCaptain of the Bluefin | Captain of the Bluefin |
| FFrank LondonAl Garrity | Al Garrity |
 Karl LukasHallert | Hallert |