Tony Rome, a tough Miami PI living on a houseboat, is hired by a local millionaire to find jewelry stolen from his daughter, and in the process has several encounters with local hoods as well as the Miami Beach PD.
| Actor | Role |
|---|---|
 Frank SinatraTony Rome | Tony Rome |
 Jill St. JohnAnn Archer | Ann Archer |
 Richard ConteLt. Dave Santini | Lt. Dave Santini |
 Gena RowlandsRita Kosterman | Rita Kosterman |
 Simon OaklandRudy Kosterman | Rudy Kosterman |
 Robert J. WilkeRalph Turpin | Ralph Turpin |
 Sue LyonDiana Pines | Diana Pines |
 Jeffrey LynnAdam Boyd | Adam Boyd |
 Lloyd BochnerVic Rood | Vic Rood |
 Virginia VincentSally Bullock | Sally Bullock |
 Joan ShawleeFat Candy | Fat Candy |
| RRichard KrisherDonald Pines | Donald Pines |
 Lloyd GoughJules Langley | Jules Langley |
 Elisabeth FraserIrene (misidentified as "Irma" in credits) | Irene (misidentified as "Irma" in credits) |
 Jeanne CooperLorna Boyd | Lorna Boyd |
 Shecky GreeneCatleg | Catleg |
| RRocky GrazianoPacky | Packy |
| SStanley RossSam Boyd | Sam Boyd |
 Joe E. RossBartender | Bartender |
 Deanna LundGeorgia Mckay | Georgia Mckay |
| MMichael RomanoffSal | Sal |
 Templeton FoxMrs. Schuyler | Mrs. Schuyler |
| HHarry DavisRuyter | Ruyter |
 Tiffany BollingPhoto Girl | Photo Girl |