Two groups of classic cartoon characters come together in this fun-filled crossover with the popular action-adventure series Jonny Quest. Fans of all ages won't want to miss this heart-stopping romp as Tom and Jerry join Jonny Quest and his pal Hadji and embark on a dangerous spy mission in order to save the world.
| Actor | Role |
|---|---|
| RReese HartwigJohnny Quest (voice) | Johnny Quest (voice) |
 James HongDr. Zin (voice) | Dr. Zin (voice) |
 Grey DeLisleCarol (voice) | Carol (voice) |
 Tim MathesonThe President (voice) | The President (voice) |
 Jess HarnellPan (voice) | Pan (voice) |
 Richard McGonagleAlley (voice) | Alley (voice) |
 Tia CarrereJezebel Jade (voice) | Jezebel Jade (voice) |
 Joe AlaskeyDroopy (voice) | Droopy (voice) |