Tom and Jerry need to learn to work together in order to help Sherlock Holmes with an investigation of a jewel theft. But still, they are cat and mouse!
| Actor | Role |
|---|---|
 Michael YorkSherlock Holmes (voice) | Sherlock Holmes (voice) |
 Malcolm McDowellProfessor Moriarity (voice) | Professor Moriarity (voice) |
 John Rhys-DaviesDr. Watson (voice) | Dr. Watson (voice) |
 Billy WestTom (voice) | Tom (voice) |
 Grey DeLisleRed (voice) | Red (voice) |
 Phil LaMarrSpike / Policeman (voice) | Spike / Policeman (voice) |
 Kath SoucieTuffy (voice) | Tuffy (voice) |
 Jeff BergmanButch / Droopy (voice) | Butch / Droopy (voice) |
 Greg EllisTin / Sergeant (voice) | Tin / Sergeant (voice) |
 Jess HarnellPan / Brett Jeremy (voice) | Pan / Brett Jeremy (voice) |
 Richard McGonagleAli / First Policeman (voice) | Ali / First Policeman (voice) |