While carrying on their usual hi-jinks, they inadvertantly stow-away on a spaceship bound for Mars. They meet up with the local Martian residents and cause them to invade the Earth, aided by the "Invincitron", a vacuum-wielding giant robot. Tom, Jerry and their Martian ally, Peep, save the day.
| Actor | Role |
|---|---|
 Jeff BennettDr. Gluckman / Martian Guard #1 / President (voice) | Dr. Gluckman / Martian Guard #1 / President (voice) |
 Corey BurtonMartian Scientist / Court Attendant / Eyes At Gate (voice) | Martian Scientist / Court Attendant / Eyes At Gate (voice) |
 Kathryn FiorePeep / Press Girl (voice) | Peep / Press Girl (voice) |
 Brad GarrettCommander Bristle / Martian Guard #3 (voice) | Commander Bristle / Martian Guard #3 (voice) |
 Jess HarnellMajor Buzz Blister / Martian General / Worker #3 (voice) | Major Buzz Blister / Martian General / Worker #3 (voice) |
 Tom KennyGrob / Gardener #1 / Martian Guard #2 (voice) | Grob / Gardener #1 / Martian Guard #2 (voice) |
 Bill KoppTom / Press Guy #1 (voice) | Tom / Press Guy #1 (voice) |
 Rob PaulsenComputer / Worker #1 / Worker #2 (voice) | Computer / Worker #1 / Worker #2 (voice) |
 Frank WelkerSpike (voice) | Spike (voice) |
 Billy WestMajor Biff Buzzard / King Thingg / Gardener #2 (voice) | Major Biff Buzzard / King Thingg / Gardener #2 (voice) |