 Matt DamonCale (voice) | Cale (voice) |
 Bill PullmanKorso (voice) | Korso (voice) |
 Drew BarrymoreAkima (voice) | Akima (voice) |
 John LeguizamoGune (voice) | Gune (voice) |
 Nathan LanePreed (voice) | Preed (voice) |
 Janeane GarofaloStith (voice) | Stith (voice) |
 Jim BreuerThe Cook (voice) | The Cook (voice) |
 Ken Hudson CampbellPo (voice) | Po (voice) |
| TThomas A. ChantlerMale Announcer (voice) | Male Announcer (voice) |
 Tsai ChinOld Woman (voice) | Old Woman (voice) |
 Elaine A. ClarkCitizen (voice) | Citizen (voice) |
| RRoy ConradSecond Human (voice) | Second Human (voice) |
 Jim CummingsChowquin (voice) | Chowquin (voice) |
| LLeslie HedgerFirst Human (voice) | First Human (voice) |
 Roger L. JacksonFirst Alien (voice) | First Alien (voice) |
 David L. LanderThe Mayor (voice) | The Mayor (voice) |
 Alex D. LinzYoung Cale (voice) | Young Cale (voice) |
 Tone LocTek (voice) | Tek (voice) |
 Ron PerlmanSam Tucker (voice) | Sam Tucker (voice) |
 Charles RocketFirrikash / Slave Trader Guard (voice) | Firrikash / Slave Trader Guard (voice) |
 Crystal ScalesDrifter Girl (voice) | Drifter Girl (voice) |
 Chris ScarabosioQueen Drej (voice) | Queen Drej (voice) |
| EEric SchniewindAlien (voice) | Alien (voice) |
 Stephen StantonColonist (voice) | Colonist (voice) |
| SScott SeymannKorso / Additional Voices (uncredited) | Korso / Additional Voices (uncredited) |
| AAlex PelsSoldier (voice) | Soldier (voice) |
| SShannon OrrockFemale Announcer (voice) | Female Announcer (voice) |
