 Jeanne TripplehornGwen Moss | Gwen Moss |
 Dylan McDermottNick | Nick |
 Kale BrowneVince Dawkan | Vince Dawkan |
 Alice DrummondHarriet | Harriet |
 Sarah Jessica ParkerFrancesca Lanfield | Francesca Lanfield |
 Jennifer AnistonDebbie | Debbie |
 Karen AllenBetty Dawkan | Betty Dawkan |
| JJoshua RubinNick, Age 12 | Nick, Age 12 |
 John PlumpisSaul, Age 25 | Saul, Age 25 |
 Janel MoloneyBeebee, Age 25 | Beebee, Age 25 |
 Yvonne ZimaGwen, Age 7 | Gwen, Age 7 |
 Christine EbersoleBeebee Moss | Beebee Moss |
| KKellen FinkNick, Age 7 | Nick, Age 7 |
 Michael TuckerSaul Moss | Saul Moss |
| AAlexandra TheriaultTaffy, Age 7 | Taffy, Age 7 |
| KKimberly PaigeTaffy, Age 12 | Taffy, Age 12 |
 Jim JansenTV Dad | TV Dad |
| SSean BolvinOne Big Happy Family Member | One Big Happy Family Member |
| KKenneth FloresOne Big Happy Family Member | One Big Happy Family Member |
| JJoette HaywardOne Big Happy Family Member | One Big Happy Family Member |
| MMary MartinOne Big Happy Family Member | One Big Happy Family Member |
| SSteven ScottOne Big Happy Family Member | One Big Happy Family Member |
| AAndrew ArmbrusterJonny, Age 8 | Jonny, Age 8 |
 Amanda FullerDebbie, Age 13 | Debbie, Age 13 |
 Madeline ZimaGwen, Age 12 | Gwen, Age 12 |
| JJohn MascaroGwen's College Date | Gwen's College Date |
| MMatt AlexanderGwen's Prom Date | Gwen's Prom Date |
 Ken OlinGregory | Gregory |
 Susan WaltersRobin | Robin |
| MMichael MoertlDean | Dean |
