An estranged man, Matt Heller, and a woman, Martha Parks, encounter each other by chance on a plane, and relive memories of their turbulent romantic relationship. Kirsty Sachs, a talk show host who has an affair with Heller and changes the course of his whirlwind relationship with Parks.
| Actor | Role |
|---|---|
 Penélope CruzMartha Parks | Martha Parks |
 Diane KrugerKirsty Sachs | Kirsty Sachs |