Pete and Debbie are both about to turn 40, their kids hate each other, both of their businesses are failing, they're on the verge of losing their house, and their relationship is threatening to fall apart.
| Actor | Role |
|---|---|
 Paul RuddPete | Pete |
 Leslie MannDebbie | Debbie |
 John LithgowOliver | Oliver |
 Megan FoxDesi | Desi |
 Maude ApatowSadie | Sadie |
 Iris ApatowCharlotte | Charlotte |
 Chris O'DowdRonnie | Ronnie |
 Jason SegelJason | Jason |
 Melissa McCarthyCatherine | Catherine |
 Graham ParkerGraham Parker | Graham Parker |
 Albert BrooksLarry | Larry |
 Lena DunhamCat | Cat |
 Annie MumoloBarb | Barb |
 Robert SmigelBarry | Barry |
 Lo MutucJodi | Jodi |
 Lisa DarrClair | Clair |
 Billie Joe ArmstrongBillie Joe Armstrong | Billie Joe Armstrong |
 Michael Ian BlackAccountant | Accountant |
 Wyatt RussellFlirty Hockey Player | Flirty Hockey Player |
 Tom YiCharlotte's Teacher | Charlotte's Teacher |
 Tim BagleyDr. Pellegrino | Dr. Pellegrino |
| AAva SamboraWendy | Wendy |
 Megan GranoSchool Playdate Parent | School Playdate Parent |
 D.A. SandovalOlder Pregnant Parent | Older Pregnant Parent |
 Derek BascoRoom Service Waiter | Room Service Waiter |
 Nicol PaoneE.R. Nurse | E.R. Nurse |
 Tom EverettPete's Doctor | Pete's Doctor |
 Tatum O'NealRealtor | Realtor |
 Ryan AdamsRyan Adams | Ryan Adams |
 Ryan LeeJoseph | Joseph |