Two codependent best friends living paycheck to paycheck and bong rip to bong rip get caught in a case of mistaken identity that throws their lives into chaos.
| Actor | Role |
|---|---|
 Kristen StewartFrankie / Frances | Frankie / Frances |
 Alia ShawkatMolly | Molly |
 LaKeith StanfieldNot Metal Head Dave | Not Metal Head Dave |
 Zack FoxJosh | Josh |
 Tony HaleMartin Flynn | Martin Flynn |
 Chris EstradaJose | Jose |
 Thomas La Barbera ChristensenAxel | Axel |
 Thor KnaiDagmar | Dagmar |
 Thomas NicholsonFritz | Fritz |
 Seth RogenDio (voice) | Dio (voice) |
 Kumail NanjianiGG (voice) | GG (voice) |
 Kate McKinnonDr. Olsen | Dr. Olsen |
 Geena DavisDr. Chapman | Dr. Chapman |
 Cate BlanchettDeep Sea Expert (voice) | Deep Sea Expert (voice) |
 Taj CrossKai | Kai |
 Morgan KrantzMike Z | Mike Z |
 Sugar Lyn BeardMr. Kock | Mr. Kock |
| ZZed CutsingerYoung Martin Flynn | Young Martin Flynn |
| MMarisa DabiceMannequin Pussy | Mannequin Pussy |
| KKaleen ReadingMannequin Pussy | Mannequin Pussy |
| CColins RegisfordMannequin Pussy | Mannequin Pussy |
| MMaxine SteenMannequin Pussy | Mannequin Pussy |