More than two-dozen music-videos directed by filmmaker Mark Romanek (One-Hour Photo) are collected together in this compilation from Palm Pictures. Among the songs featured in The Work of Director Mark Romanek are "Novocaine for the Soul" by Eels, "99 Problems" by Jay-Z, and "Hurt" by Johnny Cash.
| Actor | Role |
|---|---|
 Mark RomanekSelf - Interviewee | Self - Interviewee |
 Fiona AppleSelf - Interviewee | Self - Interviewee |
 Brian BellSelf - Interviewee | Self - Interviewee |
 Vincent GalloSelf (segment "99 Problems") | Self (segment "99 Problems") |
 David BlaineSelf (segment "Criminal") | Self (segment "Criminal") |
 BonoSelf - Interviewee | Self - Interviewee |
 David BowieSelf (archive footage) | Self (archive footage) |
 Johnny CashSelf (archive footage) | Self (archive footage) |
 Rivers CuomoSelf - Interviewee | Self - Interviewee |
 David FincherSelf - Interviewee | Self - Interviewee |
 John FruscianteSelf (archive footage) | Self (archive footage) |