 Kiefer SutherlandSamson (voice) | Samson (voice) |
 Jim BelushiBenny (voice) | Benny (voice) |
 Suzy Eddie IzzardNigel (voice) | Nigel (voice) |
 Janeane GarofaloBridget (voice) | Bridget (voice) |
 William ShatnerKazar (voice) | Kazar (voice) |
 Richard KindLarry (voice) | Larry (voice) |
 Greg CipesRyan (voice) | Ryan (voice) |
 Colin HayFergus Flamingo (voice) | Fergus Flamingo (voice) |
 Miles MarsicoDuke (voice) | Duke (voice) |
 Jack De SenaEze (voice) | Eze (voice) |
 Don CherryPenguin MC (voice) | Penguin MC (voice) |
| CChristian ArguetaHamir (voice) | Hamir (voice) |
 David CowgillHamir (voice) | Hamir (voice) |
 Lenny VenitoStan (voice) | Stan (voice) |
 Joseph SiravoCarmine (voice) | Carmine (voice) |
 Colin CunninghamHyrax (voice) | Hyrax (voice) |
 Patrick WarburtonBlag (voice) | Blag (voice) |
 Jonathan KimmelScab (voice) | Scab (voice) |
| EEddie GosslingScraw (voice) | Scraw (voice) |
 Miss Coco PeruMama Hippo (voice) | Mama Hippo (voice) |
 Jason HarrisAdditional Voices (voice) | Additional Voices (voice) |
 Kevin Michael RichardsonSamson' Father (voice) | Samson' Father (voice) |
 Jess HarnellAdditional Voices (voice) | Additional Voices (voice) |
 Fred TatascioreAdditional Voices (voice) | Additional Voices (voice) |
 Laraine NewmanAdditional Voices (voice) | Additional Voices (voice) |
 Kari WahlgrenBaby Hippo/Walla (voice) | Baby Hippo/Walla (voice) |
| SSteve WilliamsAdditional Voices (voice) | Additional Voices (voice) |
| HHannah WilliamsAdditional Voice (voice) | Additional Voice (voice) |
 Audrey WasilewskiAdditional Voice (voice) | Additional Voice (voice) |
 Peter Pamela RoseAdditional Voice (voice) | Additional Voice (voice) |
