 Lon ChaneyProfessor Echo / Granny O'Grady | Professor Echo / Granny O'Grady |
 Mae BuschRosie O'Grady | Rosie O'Grady |
 Matt MooreHector McDonald | Hector McDonald |
 Victor McLaglenHercules | Hercules |
 Harry EarlesTweedledee aka Little Willie | Tweedledee aka Little Willie |
 Matthew BetzDetective Regan | Detective Regan |
 Edward ConnellyJudge | Judge |
 William HumphreyAttorney for Defense | Attorney for Defense |
 E. Alyn WarrenProsecuting Attorney | Prosecuting Attorney |
| MMargie AngusTwin (uncredited) | Twin (uncredited) |
| MMary AngusTwin (uncredited) | Twin (uncredited) |
| WWalter P. ColeHuman Skeleton (uncredited) | Human Skeleton (uncredited) |
 Carrie DaumeryPet Shop Customer (uncredited) | Pet Shop Customer (uncredited) |
| DDelmo FritzSword Swallower (uncredited) | Sword Swallower (uncredited) |
| AAlice JulianFat Lady (uncredited) | Fat Lady (uncredited) |
| PPeter KortesSword Swallower (uncredited) | Sword Swallower (uncredited) |
 Mickey McBanBoy Watching Hercules' Act (uncredited) | Boy Watching Hercules' Act (uncredited) |
 Wilmuth MerkylJeweler (uncredited) | Jeweler (uncredited) |
| JJohn MillertaWild Borneo Man (uncredited) | Wild Borneo Man (uncredited) |
 Louis MorrisonPolice Commissioner (uncredited) | Police Commissioner (uncredited) |
| MMajorie MortonMrs. Arlington (uncredited) | Mrs. Arlington (uncredited) |
| WWalter PerryDime Museum Announcer (uncredited) | Dime Museum Announcer (uncredited) |
| LLouis ShankNewsboy (uncredited) | Newsboy (uncredited) |
| VVera VanceDancer (uncredited) | Dancer (uncredited) |
| CCharles WellesleyJohn Arlington (uncredited) | John Arlington (uncredited) |
| PPercy WilliamsButler (uncredited) | Butler (uncredited) |
