 Ron FazioThe Toxic Avenger (voice) / Apocalypse, Inc. Executive | The Toxic Avenger (voice) / Apocalypse, Inc. Executive |
 John AltamuraThe Toxic Avenger | The Toxic Avenger |
 Phoebe LegereClaire | Claire |
 Rick CollinsApocalypse, Inc. Chairman / The Devil | Apocalypse, Inc. Chairman / The Devil |
 Lisa GayeMalfaire | Malfaire |
 Jessica DublinMrs. Junko | Mrs. Junko |
| MMichael J. KaplanLittle Melvin | Little Melvin |
 Tsutomu SekineAnnouncer | Announcer |
| TTraci MannSnake Lady / Apprentice Bad Girl | Snake Lady / Apprentice Bad Girl |
 Paul BorgheseLou Sipher | Lou Sipher |
 Joe FleishakerApocalypse, Inc. Executive | Apocalypse, Inc. Executive |
 Michael Jai WhiteApocalypse, Inc. Executive | Apocalypse, Inc. Executive |
 Pericles LewnesPainted Face Villain | Painted Face Villain |
| AAra RomanoffVideo Store Employee | Video Store Employee |
 Carl BurrowsDoctor Goldberg (as Edward Burrows) | Doctor Goldberg (as Edward Burrows) |
| WWilliam E. BensonFather O'Reilly | Father O'Reilly |
 Dan SnowCigar Face | Cigar Face |
| BBonnie GarvinBad Girl | Bad Girl |
| KKaren KingBad Girl | Bad Girl |
| DDee Dee MancusoBad Girl | Bad Girl |
| MMelissa OsborneBad Girl | Bad Girl |
| HHelen WheelsBad Girl | Bad Girl |
| RRaven SkyeApprentice Bad Girl | Apprentice Bad Girl |
| FFernando AntonioApocalypse, Inc. Executive | Apocalypse, Inc. Executive |
| SSylvester CovinApocalypse, Inc. Executive | Apocalypse, Inc. Executive |
| PPaul DavisApocalypse Inc. Employee | Apocalypse Inc. Employee |
| WWilliam DeckerApocalypse Inc. Executive | Apocalypse Inc. Executive |
| MMark FucileApocalypse, Inc. Executive | Apocalypse, Inc. Executive |
