 William PowellNick Charles | Nick Charles |
 Myrna LoyNora Charles | Nora Charles |
 Lucile WatsonMrs. Marta Charles | Mrs. Marta Charles |
 Gloria DeHavenLaura Belle Ronson | Laura Belle Ronson |
 Anne RevereCrazy Mary | Crazy Mary |
 Helen VinsonHelena Draque | Helena Draque |
 Harry DavenportDr. Bertram Charles | Dr. Bertram Charles |
 Leon AmesEdgar Draque | Edgar Draque |
 Donald MeekWillie Crump | Willie Crump |
 Edward BrophyBrogan | Brogan |
 Lloyd CorriganDr. Bruce Clayworth | Dr. Bruce Clayworth |
 Anita Sharp-BolsterHilda | Hilda |
| RRalph BrookePeter Berton | Peter Berton |
 Donald MacBridePolice Chief MacGregor | Police Chief MacGregor |
 Morris AnkrumWilloughby Peavy | Willoughby Peavy |
 Nora CecilMiss Peavy | Miss Peavy |
 Minor WatsonSam Ronson | Sam Ronson |
 Irving BaconTom | Tom |
 Virginia SaleTom's Wife | Tom's Wife |
| AAsta Jr.Asta | Asta |
 Joseph CrehanClancy - Policeman at Railroad Station (uncredited) | Clancy - Policeman at Railroad Station (uncredited) |
 Tom DuganStuds Lonnegan (uncredited) | Studs Lonnegan (uncredited) |
 Wally CassellBill Burns (uncredited) | Bill Burns (uncredited) |
 Edward GarganMickey Finnegan (uncredited) | Mickey Finnegan (uncredited) |
 Rex EvansFat Man in Train Passageway (uncredited) | Fat Man in Train Passageway (uncredited) |
 Charles HaltonR.T. Tatum (uncredited) | R.T. Tatum (uncredited) |
 Paul LangtonTom Clayworth (uncredited) | Tom Clayworth (uncredited) |
 Etta McDanielRonson's Maid (uncredited) | Ronson's Maid (uncredited) |
 Clarence MusePorter on Train (uncredited) | Porter on Train (uncredited) |
 Robert Emmett O'ConnorBaggage Attendant on Train (uncredited) | Baggage Attendant on Train (uncredited) |
