Dr. Mabuse has been locked away for years in an insane asylum. Suddenly crimes start occurring and no one knows the culprit. A detective goes to visit the Doctor to find some sort of clues to the robberies.
| Actor | Role |
|---|---|
 Gert FröbeKriminalkommissar Lohmann | Kriminalkommissar Lohmann |
 Senta BergerNelly | Nelly |
 Helmut SchmidJonny Briggs | Jonny Briggs |
 Wolfgang PreissDr. Mabuse | Dr. Mabuse |
 Harald JuhnkeKriminalassistent Krüger | Kriminalassistent Krüger |
 Charles RegnierMortimer | Mortimer |
 Leon AskinFlocke | Flocke |
 Walter RillaProfessor Pohland | Professor Pohland |
 Anneli SauliWackel-Heidi | Wackel-Heidi |
| AAlbert BesslerParagraphen-Joe | Paragraphen-Joe |
| AAlain DijonRolf - Augapfel | Rolf - Augapfel |
 Zeev BerlinskyGulliver | Gulliver |
| AArthur SchilskyToni | Toni |
 Claus TinneyJack | Jack |
| AAlon D'ArmandFranky | Franky |
 Rolf EdenEddi | Eddi |
 Gerhard HartigBox-Manager | Box-Manager |
 Günter MeisnerHenry - Kurzschluß (uncredited) | Henry - Kurzschluß (uncredited) |