The Tashkent Files is a thriller that revolves around the mysterious death of India's 2nd Prime Minister Shri Lal Bahadur Shastri and attempts to uncover if he had actually died a natural death, or, as alleged, was assassinated.
| Actor | Role |
|---|---|
 Naseeruddin ShahPKR Natrajan | PKR Natrajan |
 Mithun ChakrabortyShyam Sunder Tripathi | Shyam Sunder Tripathi |
 Shweta Basu PrasadRaagini Phule | Raagini Phule |
 Asif BasraNews Channel Editor | News Channel Editor |
 Mandira BediIndira Joseph Roy | Indira Joseph Roy |
 Pallavi JoshiAiysha Ali Shah | Aiysha Ali Shah |
 Rajesh SharmaOmkar Kashyap | Omkar Kashyap |
 Vinay PathakMukhtar | Mukhtar |
 Pankaj TripathiGangaram Jha | Gangaram Jha |
 Prakash BelawadiGK Anantha Suresh | GK Anantha Suresh |
 Achint KaurMrs. Natarajan | Mrs. Natarajan |
| VV.M. BadolaNot listed | Not listed |
| PPrashantt GuptaNot listed | Not listed |
 Ankur RatheeImran Qureshi | Imran Qureshi |
| FFrancisco RaymondNot listed | Not listed |
| GGary TatonyNot listed | Not listed |