 Woody HarrelsonDr. Michael Reynolds | Dr. Michael Reynolds |
 Jon SedaBrandon 'Blue' Monroe | Brandon 'Blue' Monroe |
 Anne BancroftDr. Renata Baumbauer | Dr. Renata Baumbauer |
 Alexandra TydingsVictoria Reynolds | Victoria Reynolds |
 Matt MulhernDr. Chip Byrnes | Dr. Chip Byrnes |
 Talisa SotoNavajo Woman | Navajo Woman |
| RRichard BauerDr. Bradford | Dr. Bradford |
| VVictor AaronWebster Skyhorse | Webster Skyhorse |
 Lawrence PressmanAgent in Charge Collier | Agent in Charge Collier |
 Michael O'NeillAgent Moreland | Agent Moreland |
 Harry Carey, Jr.Cashier | Cashier |
 Carmen Dell'OreficeArabella Reynolds | Arabella Reynolds |
 Brooke AshleyCalantha Reynolds | Calantha Reynolds |
 Andrea RothHead Nurse | Head Nurse |
 Bob MinorDeputy Lynch | Deputy Lynch |
 Sal LandiDeputy #2 | Deputy #2 |
| HHarper RoismanMr. Vogel | Mr. Vogel |
 Kelly PerineFellow in Oncology | Fellow in Oncology |
 Andy BermanFellow in Oncology | Fellow in Oncology |
 Kirsten GetchellSally Byrnes | Sally Byrnes |
| EEmil AlexanderWaiter | Waiter |
 John Christian GraasYoung Michael Reynolds | Young Michael Reynolds |
 Christopher MastersonJimmy Reynolds | Jimmy Reynolds |
 Antwon TannerSmokes | Smokes |
| PPam MortonSelf | Self |
| LLinda M. DuenasWaitress | Waitress |
 Tony EpperHay Hauler | Hay Hauler |
 Mickey JonesFuzzy, Biker #1 | Fuzzy, Biker #1 |
 Gregory Scott CumminsBiker #2 | Biker #2 |
| DDouglas B. HallState Trooper | State Trooper |
