 Steven YeunBo (voice) | Bo (voice) |
 Gina RodriguezMary (voice) | Mary (voice) |
 Zachary LeviJoseph (voice) | Joseph (voice) |
 Keegan-Michael KeyDave (voice) | Dave (voice) |
 Kelly ClarksonLeah (voice) | Leah (voice) |
 Anthony AndersonZach (voice) | Zach (voice) |
 Kris KristoffersonOld Donkey (voice) | Old Donkey (voice) |
 Ving RhamesThaddeus (voice) | Thaddeus (voice) |
 Gabriel IglesiasRufus (voice) | Rufus (voice) |
 Patricia HeatonEdith (voice) | Edith (voice) |
 Kristin ChenowethAbby (voice) | Abby (voice) |
 Christopher PlummerKing Herod (voice) | King Herod (voice) |
 Aidy BryantRuth (voice) | Ruth (voice) |
 Tyler PerryCyrus (voice) | Cyrus (voice) |
 Tracy MorganFelix (voice) | Felix (voice) |
 Oprah WinfreyDeborah (voice) | Deborah (voice) |
 Mariah CareyRebecca (voice) | Rebecca (voice) |
 Phil MorrisBalthazar /Miller (voice) | Balthazar /Miller (voice) |
 Fred TatascioreMelchior / Inn keeper #1 / Pottery Vendor (voice) | Melchior / Inn keeper #1 / Pottery Vendor (voice) |
 Gregg BergerInn Keeper #3 (voice) | Inn Keeper #3 (voice) |
 Joel OsteenCaspar (voice) | Caspar (voice) |
 Lex LangHunter (voice) | Hunter (voice) |
 Melissa SturmInn Keeper #4 (voice) | Inn Keeper #4 (voice) |
 Roger Craig SmithChamberlain / Inn Keeper #5 (voice) | Chamberlain / Inn Keeper #5 (voice) |
 Kari WahlgrenAdditional Voices (voice) | Additional Voices (voice) |
 William TownsendHorse / Goat (voice) | Horse / Goat (voice) |
 Stephen ApostolinaAdditional Voices (voice) | Additional Voices (voice) |
 Kirk BailyAdditional Voices (voice) | Additional Voices (voice) |
 David CowgillAdditional Voices (voice) | Additional Voices (voice) |
 June ChristopherAdditional Voices (voice) | Additional Voices (voice) |
