 Basil RathboneSherlock Holmes | Sherlock Holmes |
 Nigel BruceDr. John H. Watson | Dr. John H. Watson |
 Gale SondergaardAdrea Spedding | Adrea Spedding |
 Dennis HoeyInsp. Lestrade | Insp. Lestrade |
 Vernon DowningNorman Locke | Norman Locke |
 Alec CraigRadlik | Radlik |
 Arthur HohlAdam Gilflower | Adam Gilflower |
 Mary GordonMrs. Hudson | Mrs. Hudson |
 Teddy InfuhrLarry (uncredited) | Larry (uncredited) |
 Donald StuartArtie - Shooting Gallery Attendant (uncredited) | Artie - Shooting Gallery Attendant (uncredited) |
 Harry CordingFred Garvin (uncredited) | Fred Garvin (uncredited) |
 Belle MitchellFortune Teller (uncredited) | Fortune Teller (uncredited) |
 Angelo RossittoObongo - Pygmy (uncredited) | Obongo - Pygmy (uncredited) |
 Sylvia AndrewCharwoman (uncredited) | Charwoman (uncredited) |
| MMarie De BeckerCharwoman (uncredited) | Charwoman (uncredited) |
 Jimmy AubreyNews Vendor (uncredited) | News Vendor (uncredited) |
| BBrandon BeachCarnival Patron (uncredited) | Carnival Patron (uncredited) |
| FFrank BensonToy Doll Attendant (uncredited) | Toy Doll Attendant (uncredited) |
 Lydia BilbrookSusan (uncredited) | Susan (uncredited) |
| JJohn BurtonRadio Announcer (uncredited) | Radio Announcer (uncredited) |
| JJames CarlisleCasino Patron (uncredited) | Casino Patron (uncredited) |
| JJack DeeryCasino Patron (uncredited) | Casino Patron (uncredited) |
| GGeorge KirbyNews Vendor (uncredited) | News Vendor (uncredited) |
 Stanley LoganRobert (uncredited) | Robert (uncredited) |
 Wilbur MackCasino Patron (uncredited) | Casino Patron (uncredited) |
| EEdmund MortimerCasino Patron (uncredited) | Casino Patron (uncredited) |
 William H. O'BrienDoorman (uncredited) | Doorman (uncredited) |
 John RocheCasino Croupier (uncredited) | Casino Croupier (uncredited) |
 Gene RothHenchman Taylor (uncredited) | Henchman Taylor (uncredited) |
| AArthur StenningPlainclothesman (uncredited) | Plainclothesman (uncredited) |
