 Channing TatumJonathan 'Milk' White | Jonathan 'Milk' White |
 Al PacinoDetective Charles Stanford | Detective Charles Stanford |
 Juliette BinocheLauren Bridges | Lauren Bridges |
 Katie HolmesKerry White | Kerry White |
 James RansoneOfficer Thomas Prudenti | Officer Thomas Prudenti |
 Ray LiottaCaptain Marion Mathers | Captain Marion Mathers |
 Tracy MorganVincent Carter (Adult) | Vincent Carter (Adult) |
 Ursula ParkerCharolette 'Charlie' White | Charolette 'Charlie' White |
 Brian GilbertYoung Vinnie (Carter) | Young Vinnie (Carter) |
 Jake CherryJonathan 'Milk' White (Young) | Jonathan 'Milk' White (Young) |
 Simone Joy JonesYoung Vicky | Young Vicky |
| LLemon AndersenGeronimo | Geronimo |
 Roger Guenveur SmithHanky | Hanky |
| MMichael RiveraDominican Nada Puerto Rican | Dominican Nada Puerto Rican |
| KKaren Christie-WardOlive Oil | Olive Oil |
 Johnnie MaeVinny's Mother | Vinny's Mother |
 Oberon K.A. AdjepongVinny's Mother's Boyfriend | Vinny's Mother's Boyfriend |
 Pat KiernanNews Reporter #1 | News Reporter #1 |
 Gisella MarengoNews Reporter #2 | News Reporter #2 |
 Ralph RodriguezSientate Rodriguez | Sientate Rodriguez |
