 Robert Downey Jr.Steve Lopez | Steve Lopez |
 Jamie FoxxNathaniel Ayers | Nathaniel Ayers |
 Catherine KeenerMary Weston | Mary Weston |
 Tom HollanderGraham Claydon | Graham Claydon |
 Nelsan EllisDavid Carter | David Carter |
 Michael BuninAdam Crane | Adam Crane |
 LisaGay HamiltonJennifer Ayers | Jennifer Ayers |
 Rachael HarrisLeslie Bloom | Leslie Bloom |
 Stephen RootCurt Reynolds | Curt Reynolds |
 Lorraine ToussaintFlo Ayers | Flo Ayers |
 Jena MaloneCheery Lab Tech | Cheery Lab Tech |
 Octavia SpencerTroubled Woman | Troubled Woman |
 Justin MartinYoung Nathaniel | Young Nathaniel |
| KKokayi AmpahBernie Carpenter | Bernie Carpenter |
 Patrick TattenPaul Jr. | Paul Jr. |
 Susane LeeMarisa | Marisa |
 Marcos De SilvasMayor Villaigosa | Mayor Villaigosa |
 Ilia VolokHarry Barnoff | Harry Barnoff |
| MMike NowakJulliard Conductor | Julliard Conductor |
 David Jean ThomasAngry Homeless Man | Angry Homeless Man |
| LLemon AndersenUncle Tommy | Uncle Tommy |
| KKevin Michael KeyHomeless Transvestite | Homeless Transvestite |
 Moya BradyBarely Dressed Woman | Barely Dressed Woman |
 Orlando AshleyLAMP Homeless Guy | LAMP Homeless Guy |
 Artel GreatLeon | Leon |
 J.J. BooneShouting Woman | Shouting Woman |
| AAnnie McKnightLAMP Advocate | LAMP Advocate |
| BBernadette SpeakesHomeless Lady | Homeless Lady |
| AAnna LevinLeeann | Leeann |
| SSteve FosterSteve | Steve |
