 Jacqueline BissetFrances | Frances |
 Martha PlimptonRebecca | Rebecca |
 Nick StahlMorgan | Morgan |
 Amy MadiganMaggie | Maggie |
 Frankie FaisonJimmy Dupree | Jimmy Dupree |
 Carmen ZapataAnna | Anna |
 Peggy GormleyBetty | Betty |
 Seymour CasselBob | Bob |
 Justin TherouxRebecca's Boyfriend | Rebecca's Boyfriend |
 Kate McGregor-StewartMiriam | Miriam |
 Molly PriceRebecca's Colleague | Rebecca's Colleague |
 Clara BellarMushroom Girl | Mushroom Girl |
 Mark TymchyshynLarry Mosher | Larry Mosher |
 Anibal O. LlerasMr. Vega | Mr. Vega |
 Phyllis SomervilleRebecca's Adoptive Mother | Rebecca's Adoptive Mother |
 Robert HoganRebecca's Adoptive Father (as Bob Hogan) | Rebecca's Adoptive Father (as Bob Hogan) |
 Lola PashalinskiAdoption Agency Director | Adoption Agency Director |
 Robin WeigertHospital Records Keeper | Hospital Records Keeper |
| JJohnny ArkooshNaked Boy (as John Arkoosh) | Naked Boy (as John Arkoosh) |
 Rain PhoenixWROD Receptionist | WROD Receptionist |
 Jessica Brooks GrantFrances - Aged 10 and 14 | Frances - Aged 10 and 14 |
| RRandall SlavinRich | Rich |
| LLouise FernandezFrances - aged 3 | Frances - aged 3 |
| EE. HernandezFrances's Father | Frances's Father |
 Kimberly ScottEmergency Room Nurse | Emergency Room Nurse |
 Sarah LassezFrances - aged 25 | Frances - aged 25 |
| AAaron Amara DavisJimmy - aged 25 | Jimmy - aged 25 |
| PPepe AtramontesLa Llorona Guitarist | La Llorona Guitarist |
 Stephanie Barton-FarcasRebecca's Law Firm Partner (uncredited) | Rebecca's Law Firm Partner (uncredited) |
