A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.
| Actor | Role |
|---|---|
 Arthur WontnerSherlock Holmes | Sherlock Holmes |
 Isla BevanMary Morstan | Mary Morstan |
 Ian HunterDr. John Watson | Dr. John Watson |
| GGraham SouttenJonathan Small | Jonathan Small |
 Herbert LomasMaj. John Sholto | Maj. John Sholto |
| GGilbert DavisDet. Insp. Atherly Jones | Det. Insp. Atherly Jones |
 Margaret YardeMrs. Smith | Mrs. Smith |
 Roy EmertonThe Tattooed Man | The Tattooed Man |
| MMr. BurnhettTattoo Artist | Tattoo Artist |
 Charles FarrellFunfair Patron | Funfair Patron |
 Clare GreetMrs. Hudson | Mrs. Hudson |
 Moore MarriottMordecai Smith | Mordecai Smith |
| EEdgar NorfolkCapt. Morstan | Capt. Morstan |
 Kynaston ReevesBartholomew Sholto | Bartholomew Sholto |
| EErnest SeftonBarrett | Barrett |
| TTogoTonga | Tonga |
 Miles MallesonThaddeus Sholto | Thaddeus Sholto |