When sleuth Nayland Smith steals evil Dr Fu-Manchu's 'Sacred Order', the Devil Doctor himself faces death at the hands of the Si-Fan organisation.
| Actor | Role |
|---|---|
| HH. Agar LyonsDr. Fu Manchu | Dr. Fu Manchu |
 Fred PaulNayland Smith | Nayland Smith |
| JJoan ClarksonKaramaneh | Karamaneh |
| HHumberston WrightDr. Petrie | Dr. Petrie |
 Frank WilsonInspector Weymouth | Inspector Weymouth |
| PPercy ClarbourInspector Wills | Inspector Wills |
| LLaurie LeslieDacoit | Dacoit |
| HH. ManningMandarin | Mandarin |