 Whoopi GoldbergRanger Margaret (voice) | Ranger Margaret (voice) |
 David SpadeRanger Frank (voice) | Ranger Frank (voice) |
 E. G. DailyTommy Pickles (voice) | Tommy Pickles (voice) |
 Tara StrongDilan "Dil" Pickles (voice) | Dilan "Dil" Pickles (voice) |
 Christine CavanaughChuckie Finster (voice) | Chuckie Finster (voice) |
 Kath SouciePhil / Lil / Betty DeVille (voices) | Phil / Lil / Betty DeVille (voices) |
 Cheryl ChaseAngelica Pickles (voice) | Angelica Pickles (voice) |
 Tim CurryRex Pester (voice) | Rex Pester (voice) |
 Jack RileyStuart 'Stu' Pickles (voice) | Stuart 'Stu' Pickles (voice) |
 Busta RhymesReptar Wagon (voice) | Reptar Wagon (voice) |
 Michael BellCharles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice) | Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice) |
 Joe AlaskeyGrandpa Lou Pickles (voice) | Grandpa Lou Pickles (voice) |
 Phil ProctorHoward DeVille / Igor (voice) | Howard DeVille / Igor (voice) |
 Cree SummerSusie Carmichael (voice) | Susie Carmichael (voice) |
 Tress MacNeilleCharlotte Pickles (voice) | Charlotte Pickles (voice) |
 Melanie ChartoffDidi Pickles / Minka Kropotkin (voice) | Didi Pickles / Minka Kropotkin (voice) |
 Hattie WinstonLucy Carmichael (voice) | Lucy Carmichael (voice) |
 Andrea MartinAunt Miriam (voice) | Aunt Miriam (voice) |
 Tony JayDr. Lipschitz (voice) | Dr. Lipschitz (voice) |
 Abraham BenrubiSerge (voice) | Serge (voice) |
 Gregg BergerTV Announcer (voice) | TV Announcer (voice) |
 Charlie AdlerUnited Express Driver (voice) | United Express Driver (voice) |
 Mary GrossFemale Guest (voice) | Female Guest (voice) |
 Edie McClurgNurse (voice) | Nurse (voice) |
 Roger Clinton Jr.Air Crewman (voice) | Air Crewman (voice) |
 Margaret ChoLt. Klavin (voice) | Lt. Klavin (voice) |
 Iggy PopNewborn Baby (singing voice) | Newborn Baby (singing voice) |
| LLouis FresseNewborn Baby (singing voice) | Newborn Baby (singing voice) |
 Lisa LoebNewborn Baby (singing voice) | Newborn Baby (singing voice) |
 Lenny KravitzNewborn Baby (singing voice) | Newborn Baby (singing voice) |
