In 1930s, hard-working girl Betty Boop sings at nights at her uncle Mischa's popular NY nightclub and dreams of marrying a posh rich playboy, Waldo. Gangster Johnny "Throat" and a nice hard-working ice-seller, Freddy, also woo her.
| Actor | Role |
|---|---|
 Desiree GoyetteBetty Boop (voice) | Betty Boop (voice) |
| SSean AllanFreddy (voice) | Freddy (voice) |
 Derek McGrathWaldo Van Lavish (voice) | Waldo Van Lavish (voice) |
 George WendtJohnny Throat/Punchie (voice) | Johnny Throat/Punchie (voice) |
 Sandy KenyonUncle Mischa Bubbles (voice) | Uncle Mischa Bubbles (voice) |
 Frank BuxtonParrot (voice) | Parrot (voice) |
 Robert TowersChuckles (voice) | Chuckles (voice) |
| RRon FriedmanEthnic Voices (voice) | Ethnic Voices (voice) |
 John StephensonAnnouncer (voice) | Announcer (voice) |
| MMarsha MeyersBeverly | Beverly |