The film follows 24 hours in the life of father and daughter Leo and Molly, as they weave their way around New York City, until their ordinary but stressful day takes on a hallucinatory and epic quality.
| Actor | Role |
|---|---|
 Javier BardemLeo | Leo |
 Elle FanningMolly | Molly |
 Salma Hayek PinaultDolores | Dolores |
 Laura LinneyRita | Rita |
 Branka KatićXenia | Xenia |
 Dimitri AndreasMikael | Mikael |
| KKatia Mullova-BrindMel | Mel |
 Milena TscharntkeAnni | Anni |
| DDebora WestonDentist | Dentist |
 Aaron JoshuaTaxi Driver | Taxi Driver |
| SSabina CameronNurse | Nurse |
 Griffin StevensDoctor | Doctor |
| CCatherine LeviClio | Clio |
| RRuth KeelingWoman Jogger | Woman Jogger |
 Olan MontgomerySecurity Guard | Security Guard |
 Cory PetersonOptometrist | Optometrist |
 Waleed AkhtarRahim | Rahim |
| RRay JahanTazeem | Tazeem |
| GGerard CorderoPolice Officer Amenta | Police Officer Amenta |
| JJosé Boza GonzálezFisherman | Fisherman |
 Leesa KimAdam's Assistant | Adam's Assistant |
| GGeorge MizenTeenage Boy | Teenage Boy |
 Davina SitaramShopper with Phone (uncredited) | Shopper with Phone (uncredited) |