 Matt DamonLieutenant Dane Dumars | Lieutenant Dane Dumars |
 Ben AffleckDetective Sergeant J.D. Byrne | Detective Sergeant J.D. Byrne |
 Teyana TaylorDetective Numa Baptistie | Detective Numa Baptistie |
 Steven YeunDetective Mike Ro | Detective Mike Ro |
 Catalina Sandino MorenoDetective Lolo Salazar | Detective Lolo Salazar |
 Sasha CalleDesiree 'Desi' Lopez Molina | Desiree 'Desi' Lopez Molina |
 Kyle ChandlerDEA Agent Mateo 'Matty' Nix | DEA Agent Mateo 'Matty' Nix |
 Scott AdkinsFBI Agent Del Byrne | FBI Agent Del Byrne |
 Daisuke TsujiFBI Agent Logan Casiano | FBI Agent Logan Casiano |
 Nestor CarbonellMajor Thom Vallejo | Major Thom Vallejo |
 Lina EscoCaptain Jackie Velez | Captain Jackie Velez |
 Alex HernandezHialeah Patrolman Warwick | Hialeah Patrolman Warwick |
 Cliff ChamberlainHialeah Patrolman Junger | Hialeah Patrolman Junger |
 Jose Pablo CantilloDEA Agent Dayo Reyes | DEA Agent Dayo Reyes |
 Marco MoralesCartel Lookout | Cartel Lookout |
 Sal LopezMr. Zeltzin | Mr. Zeltzin |
 Angel Rosario Jr.Grizzled Carter Man | Grizzled Carter Man |
 David Anthony BuglioneFBI Tactical Sniper | FBI Tactical Sniper |
 Lourdes HernándezTNT Detective Hernandez | TNT Detective Hernandez |
 Joe CarnahanThreatening Phone Voice | Threatening Phone Voice |
 Joel PerezTNT Detective Perez | TNT Detective Perez |
| RRani BalsamoDEA Official | DEA Official |
| JJayson MerrillLead DEA Official | Lead DEA Official |
| JJohn P. BradyDEA Official | DEA Official |
| JJoe Wanjai RossDEA Official | DEA Official |
| IIsabella AparicioLittle Girl Jackie | Little Girl Jackie |
| CChristopher SilvestriDEA Agent | DEA Agent |
| RRockne CarnahanDEA Medical Staff | DEA Medical Staff |
| CChris CasianoTNT Detective Al Pardo | TNT Detective Al Pardo |
| JJovan PerezTNT Detective J. Perez | TNT Detective J. Perez |
