The Return of Sherlock Holmes was the first sound film to feature Sherlock Holmes.
| Actor | Role |
|---|---|
 Clive BrookSherlock Holmes | Sherlock Holmes |
| HH. Reeves-SmithDr. Watson | Dr. Watson |
 Betty LawfordMary Watson | Mary Watson |
| CCharles HayCaptain Longmore | Captain Longmore |
 Phillips HolmesRoger Longmore | Roger Longmore |
 Donald CrispColonel Moran | Colonel Moran |
 Harry T. MoreyProfessor Moriarty | Professor Moriarty |
| HHubert DruceSergeant Gripper | Sergeant Gripper |