Sherlock Holmes is brought back to life by Watson's female descendant after being cryogenically frozen for eighty years.
| Actor | Role |
|---|---|
 Margaret ColinJane Watson | Jane Watson |
 Lila KayeMs. Houston | Ms. Houston |
 Connie BoothViolet Morstan | Violet Morstan |
 Nicholas GuestToby Gregory | Toby Gregory |
 Michael PenningtonSherlock Holmes | Sherlock Holmes |
 Barry MorseCarter Morstan | Carter Morstan |
 William HootkinsMyron Spellman | Myron Spellman |
 Tony SteedmanThe Doctor | The Doctor |
 Paul MaxwellAgent Hopkins | Agent Hopkins |
 Shane RimmerLisander Stark | Lisander Stark |
 Olivier PierreHampton | Hampton |
| SSheila BrandKitty Horowitz | Kitty Horowitz |
| RRay JewersSinger | Singer |
 Daniel BenzaliCharles Ross | Charles Ross |
| SSneh GuptaNot listed | Not listed |
 Ricco RossMatthew | Matthew |
 Nancy PaulNot listed | Not listed |
| DDebora WestonNot listed | Not listed |
| HHubert TuckerNot listed | Not listed |
| HHoward SwinsonNot listed | Not listed |
| JJohn SterlandNot listed | Not listed |
 Miles RichardsonBarton | Barton |