The sinister Dr. Fu Manchu returns to destroy the people he holds responsible for the death of his family.
| Actor | Role |
|---|---|
 Warner OlandDr. Fu Manchu | Dr. Fu Manchu |
 O. P. HeggieInspector Nayland Smith | Inspector Nayland Smith |
 Jean ArthurLia Eltham | Lia Eltham |
 Neil HamiltonDr. Jack Petrie | Dr. Jack Petrie |
 Evelyn HallLady Agatha Bartley | Lady Agatha Bartley |
 William AustinSylvester Wadsworth | Sylvester Wadsworth |
 Margaret FealyLady Helen Bartley | Lady Helen Bartley |
 Shayle GardnerDetective Harding | Detective Harding |
 Evelyn SelbieFai Lu | Fai Lu |
 Ambrose BarkerNot listed | Not listed |
 Nora CecilNot listed | Not listed |
| DDavid DunbarNot listed | Not listed |
 Bill ElliottNot listed | Not listed |
 Toyo FujitaNot listed | Not listed |
 Olaf HyttenNot listed | Not listed |
 Tetsu KomaiNot listed | Not listed |
 Will StantonNot listed | Not listed |