 Bob NewhartBernard (voice) | Bernard (voice) |
 Eva GaborMiss Bianca (voice) | Miss Bianca (voice) |
 John CandyWilbur (voice) | Wilbur (voice) |
 Tristan RogersJake (voice) | Jake (voice) |
| AAdam RyenCody (voice) | Cody (voice) |
 George C. ScottMcLeach (voice) | McLeach (voice) |
 Wayne RobsonFrank (voice) | Frank (voice) |
 Douglas SealeKrebbs (voice) | Krebbs (voice) |
 Frank WelkerJoanna / Marahute (voice) | Joanna / Marahute (voice) |
 Bernard FoxChairman / Doctor (voice) | Chairman / Doctor (voice) |
 Peter FirthRed (voice) | Red (voice) |
 Ed GilbertFrancois (voice) | Francois (voice) |
 Carla MeyerFaloo / Mother (voice) | Faloo / Mother (voice) |
 Russi TaylorNurse Mouse (voice) | Nurse Mouse (voice) |
 Peter GreenwoodRadio Announcer / Airplane Captain (voice) | Radio Announcer / Airplane Captain (voice) |
 Billy BartyBaitmouse (voice) | Baitmouse (voice) |
 Mickie McGowanInternational Mice (voice) (uncredited) | International Mice (voice) (uncredited) |
 Charlie AdlerAdditional Voices (voice) | Additional Voices (voice) |
 Jack AngelAdditional Voices (voice) | Additional Voices (voice) |
 Vanna BontaAdditional Voices (voice) | Additional Voices (voice) |
| MMarii MakAdditional Voices (voice) | Additional Voices (voice) |
 Patrick PinneyAdditional Voices (voice) | Additional Voices (voice) |
 Phil ProctorAdditional Voices (voice) | Additional Voices (voice) |
