Miner Kate Nelson strikes gold but is quickly robbed at a frontier hotel by a desperate Mexican woman, who shoots a hotel clerk during her escape. The thief hides with an Indian girl and her half-breed husband. She seduces the husband into helping her torture and hang his Indian wife over a river. After bravely escaping her bonds, the Red Girl guides Kate and a posse in a thrilling canoe chase. Following a dramatic underwater battle, the culprits are captured. The husband tries to reconcile with his wife, but she rejects him, finding solace and friendship in Kate's embrace.
| Actor | Role |
|---|---|
 Florence LawrenceThe Red Girl | The Red Girl |
 Charles InsleeThe Red Girl's Husband | The Red Girl's Husband |
 Linda ArvidsonWoman in Second Bar | Woman in Second Bar |
 Clara T. BracyNot listed | Not listed |
 George GebhardtIndian / Man in First Bar / Man in Second Bar | Indian / Man in First Bar / Man in Second Bar |
 D.W. GriffithMan on Footpath | Man on Footpath |
 Arthur V. JohnsonNot listed | Not listed |
| AAnthony O'SullivanNot listed | Not listed |
 Mack SennettMan in First Bar / Man in Second Bar | Man in First Bar / Man in Second Bar |
 Harry SolterBartender | Bartender |
 Marion SunshineNot listed | Not listed |