An aspiring actor and his girlfriend handle life's frustrations, while his friend seeks fulfillment with a blonde.
| Actor | Role |
|---|---|
 Matthew ModineJoe | Joe |
 Catherine KeenerMary | Mary |
 Daryl HannahKelly | Kelly |
 Maxwell CaulfieldBob | Bob |
 Elizabeth BerkleyTina | Tina |
 Marlo ThomasBlair | Blair |
 Bridgette WilsonSahara | Sahara |
 Buck HenryDr. Leuter | Dr. Leuter |
 Christopher LloydErnst | Ernst |
 Kathleen TurnerDee Dee Taylor | Dee Dee Taylor |
 Denis LearyDoug | Doug |
 Beatrice WindeWilma | Wilma |
 John TormeyHarassing Man | Harassing Man |
 Ali WentworthRaina | Raina |
 Debra McGrathCis | Cis |
 Nahanni JohnstoneYoung Woman | Young Woman |
 Alex AppelSheila | Sheila |
 Steve BuscemiNick | Nick |
 Dave ChappelleZee | Zee |
 Landy CannonBeach Boy | Beach Boy |
 Katie GriffinEmpty V Interviewer | Empty V Interviewer |
 Missy YagerLisa | Lisa |
| KKaren WoolridgeNadia | Nadia |
 Daniel von BargenDevon | Devon |